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Gap 27(trifluoroacetate salt)
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Gap 27(trifluoroacetate salt)图片
包装与价格：
包装 价格(元)
500 ?g 电议
1mg 电议
5mg 电议
10mg 电议

半岛bd体育手机客户端 介绍
A connexin-mimetic peptide
Canonical SMILES OC[C@H](N)C(N[C@@H](CCCNC(N)=N)C(N1[C@@H](CCC1)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(O)=O)[C@@H](C)CC)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
分子式 C60H101N15O17·XCF3COOH
分子量 1304.6
溶解度 DMSO: slightly soluble,Ethanol: slightly soluble,Methanol: slightly soluble
储存条件 -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

Gap 27 is a connexin-mimetic peptide that corresponds to amino acids 204-214 of extracellular loop 2 in connexin 43.1It reduces survival of isolated rat osteoclasts when used at a concentration of 500 ?M and decreases bone resorption in rat bone slice and osteoclast co-cultures.2Gap 27 accelerates wound closure and stratification of the corneal epithelium in isolated human corneas.3In vivo, Gap 27 reduces cardiac remodeling and the incidence of cardiac arrhythmias in a rat model of arterio-venous fistula (AV-shunt) surgery-induced high-output heart failure.4

1.Wright, C.S., Pollok, S., Flint, D.J., et al.The connexin mimetic peptide Gap27 increases human dermal fibroblast migration in hyperglycemic and hyperinsulinemic conditions in vitroJ. Cell. Physiol.227(1)77-87(2012) 2.Ilvesaro, J., Tavi, P., and Tuukkanen, J.Connexin-mimetic peptide Gap 27 decreases osteoclastic activityBMC Musculoskelet. Disord.210(2001) 3.Elbadawy, H.M., Mirabelli, P., Xeroudaki, M., et al.Effect of connexin 43 inhibition by the mimetic peptide Gap27 on corneal wound healing, inflammation and neovascularizationBr. J. Pharmacol.173(19)2880-2893(2016) 4.Lucero, C.M., Andrade, D.C., Toledo, C., et al.Cardiac remodeling and arrhythmogenesis are ameliorated by administration of Cx43 mimetic peptide Gap27 in heart failure ratsSci. Rep.10(1)6878(2020)
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