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SS-208
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
SS-208图片
CAS NO: 2245942-72-5
包装与价格：
包装 价格(元)
1mg 电议
5mg 电议
10mg 电议
25mg 电议

半岛bd体育手机客户端 介绍
SS-208 是一种选择性 HDAC6 抑制剂，IC50 为 12 nM。 SS-208 在黑色素瘤中具有抗肿瘤活性。
Cas No. 2245942-72-5
Canonical SMILES ClC1=C(Cl)C=C(C(NCCC2=CC(C(NO)=O)=NO2)=O)C=C1
分子式 C13H11Cl2N3O4
分子量 344.2
溶解度 DMF: 1mg/mL,DMSO: 1mg/mL,Ethanol: 30mg/mL,Ethanol:PBS (pH 7.2) (1:2): 0.3mg/mL
储存条件 Store at -20°C,unstable in solution, ready to use.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

SS-208 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 12 nM).1 It is selective for HDAC6 over HDAC1, -4, -5, -7, -8, -9, and -11 (IC50s = 1.39, 19.5, 6.91, 8.34, 1.23, 38.2, and 5.12 μM, respectively). SS-208 (0.1-25 μM) inhibits HDAC6 in, but does not induce cell death of, human PC3 prostate, 5637 and T24 bladder, and murine SM1 melanoma cells in vitro. It decreases protein levels of programmed death ligand 1 (PD-L1) in SM1 cells when used at a concentration of 5 μM. SS-208 (25 mg/kg, i.p.) reduces tumor growth and increases the number of intratumoral CD8+, CD4+, and natural killer (NK) T cells in an SM1 murine melanoma model.

|1. Shen, S., Hadley, M., Ustinova, K., et al. Discovery of a new isoxazole-3-hydroxamate-based histone deacetylase 6 inhibitor SS-208 with antitumor activity in syngeneic melanoma mouse models. J. Med. Chem. 62(18), 8557-8577 (2019).
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