Nuclear receptor-binding SET domain (NSD) 3 antagonist; selectively binds PWWP1 domain
| Canonical SMILES |
CN1C=NC(C2=C(C=C(C=C2C)CN)C)=C1C3=C4C=CC(F)=CC4=NC=C3.Cl.Cl.Cl |
| 分子式 |
C22H21FN4.3HCl |
| 分子量 |
469.81 |
| 溶解度 |
Soluble in DMSO |
| 储存条件 |
Store at -20°C |
| General tips |
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition |
Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 半岛bd体育手机客户端 描述 |
Nuclear receptor-binding SET domain (NSD) 3 antagonist (IC50 = 1.2 μM). Selectively binds the PWWP1 domain of NSD3 (Kd = 166 nM). Antagonizes the interaction of H3 with NSD3-PWWP1 in U2OS cells. B?ttcher et al (2019) Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nat.Chem.Biol. 15 822 PMID:31285596 |
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