生物活性

SC79是AKT激活剂。SC79绑定到模仿PtdIns（3,4,5）P3的结合的Akt的plecktrin同源（PH）域，以诱导Akt的构象变化，从而增强磷酸化和激活。

靶点信息

Akt

化学数据

目录号	A15541
作用机制	Activator (激活剂)
M. Wt	364.78
Formula	C17H17ClN2O5
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	305834-79-1
Synonyms	SC 79, SC-79
SMILES	ClC1=CC=C(OC(N)=C(C(OCC)=O)C2C(C#N)C(OCC)=O)C2=C1

溶解度

In vitro (25°C)	DMSO	61 mg/mL (167.22 mM)
	Water	Insoluble
	Ethanol	Warmed: 61 mg/mL (167.22 mM)
In vivo	2% DMSO+corn oil	4 mg/mL
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.41 mL	137.07 mL	274.14 mL
0.5 mM	5.48 mL	27.41 mL	54.83 mL
1 mM	2.74 mL	13.71 mL	27.41 mL
5 mM	0.55 mL	2.74 mL	5.48 mL

*The above data is based on the productmolecular weight 364.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.