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PRGL493

本半岛bd体育手机客户端不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2479378-45-3

包装与价格：

半岛bd体育手机客户端介绍

PRGL493 是一种有效的选择性长链酰基辅酶A 合成酶 4 (ACSL4) 抑制剂。 PRGL493 阻断乳腺和前列腺细胞和动物模型中的细胞增殖和肿瘤生长。 PRGL493 用于癌症研究。

Cas No.	2479378-45-3
Canonical SMILES	CC(NC1=NC2=NC3=C(C=CC=C3)N2C(C4=CN(C5=CC=CC=C5)N=C4C6=CC=C(C)O6)N1)=O
分子式	C₂₅H₂₁N₇O₂
分子量	451.5
溶解度	Chloroform: 1 mg/ml
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端描述	PRGL493 is an inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4).¹It inhibits formation of arachidonoyl-CoA (AA-CoA) from arachidonic acid in, as well as the proliferation and migration of, PC3 and MDA-MB-231 cancer cells when used at a concentration of 50 ?M. PRGL493 (5 ?M) reduces production of progesterone induced by 8-Br-cyclic AMP (8-Br-cAMP) in MA-10 Leydig tumor cells. It inhibits tumor growth in a PC3 mouse xenograft model when administered at a dose of 0.25 mg/kg. 1.Castillo, A.F., Orlando, U.D., Maloberti, P.M., et al.New inhibitor targeting Acyl-CoA synthetase 4 reduces breast and prostate tumor growth, therapeutic resistance and steroidogenesisCell. Mol. Life Sci.(2020)