| CAS NO: | 1188263-47-9 |
| 包装 | 价格(元) |
| 500 μg | 电议 |
| 1mg | 电议 |
| 5 mg | 电议 |
| Cas No. | 1188263-47-9 |
| 别名 | 雷洛昔芬-D4,盐酸盐 |
| Canonical SMILES | OC1=CC=C(C(C(C2=CC=C(OC([2H])([2H])C([2H])([2H])N3CCCCC3)C=C2)=O)=C(C4=CC=C(O)C=C4)S5)C5=C1.Cl |
| 分子式 | C28H23D4NO4S.HCl |
| 分子量 | 514.1 |
| 储存条件 | Store at 2°C to 8°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 半岛bd体育手机客户端 描述 | Raloxifene-d4is intended for use as an internal standard for the quantification of raloxifene by GC- or LC-MS. Raloxifene is a selective estrogen receptor modulator (SERM) that exhibits estrogenic activity in bone cells without stimulating breast or uterine tissues.1Raloxifene guards endothelial cells obtained from rat aortic rings against oxidative insult (1 ?M) and lowers serum cholesterol in ovariectomized rodents (ED50= 0.2 mg/kg).2,1Formulations containing raloxifene have been shown to reduce bone resorption and promote bone formation in post-menopausal women.3 1.Black, L.J., Sato, M., Rowley, E.R., et al.Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized ratsJ. Clin. Invest.93(1)63-69(1994) 2.Wong, C.M., Yung, L.M., Leung, F.P., et al.Raloxifene protects endothelial cell function against oxidative stressBr. J. Pharmac.155(3)326-334(2008) 3.?zmen, B., Kirmaz, C., Aydin, K., et al.Influence of the selective oestrogen receptor modulator (raloxifene hydrochloride) on IL-6, TNF-α, TGF-?1 and bone turnover markers in the treatment of postmenopausal osteoporosisEur. Cyto. Netw.18(3)148-153(2007) |
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