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3,5-Diiodo-L-thyronine
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
3,5-Diiodo-L-thyronine图片
CAS NO: 1041-01-6
包装与价格：
包装 价格(元)
500mg 电议
1 g 电议
5 g 电议
10 g 电议

半岛bd体育手机客户端 介绍
3,5-Dioodo-L-thyronine 是一种内源性代谢物。
Cas No. 1041-01-6
别名 3,5-二碘-L-甲状腺素,3,5-Diiodo-L-thyronine
Canonical SMILES IC(C=C(C=C1I)C[C@H](N)C(O)=O)=C1OC2=CC=C(C=C2)O
分子式 C15H13I2NO4
分子量 525.1
溶解度 DMF: 1 mg/ml,DMSO: insol,Ethanol: insol,PBS (pH 7.2): insol
储存条件 -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

3,5-Diiodo-L-thyronine (3,5-T2) is a thyroid hormone metabolite.1It binds to thyroid hormone receptor α1(TRα1), TRβ1, and TRβ2(EC50s = 0.8, 0.79, and 0.1 ?M, respectively, in cell-free assays).23,5-T2 (1 pM) stimulates oxygen consumption in perfused livers isolated from rats with hypothyroidism induced by sodium iodide.3It reduces subcutaneous and epididymal fat mass, as well as decreases serum leptin and cholesterol levels, without affecting body weight in high-fat diet-induced obese mice when administered at a dose of 2.5 ?g/g per day.1

1.Jonas, W., Lietzow, J., Wohlgemuth, F., et al.3,5-Diiodo-L-thyronine (3,5-T2) exerts thyromimetic effects on hypothalamus-pituitary-thyroid axis, body composition, and energy metabolism in male diet-induced obese miceEndocrinology156(1)389-399(2015) 2.Ball, S.G., Sokolov, J., and Chin, W.W.3,5-Diiodo-L-thyronine (T2) has selective thyromimetic effects in vivo and in vitroJ. Mol. Endocrinol.19(2)137-147(1997) 3.Horst, C., Rokos, H., and Seitz, H.J.Rapid stimulation of hepatic oxygen consumption by 3,5-di-iodo-?-thyronineBiochem. J.261(3)945-950(1989)
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