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Guanylin(human)(trifluoroacetate salt)
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Guanylin(human)(trifluoroacetate salt)图片
包装与价格：
包装 价格(元)
500 ?g 电议
1mg 电议

半岛bd体育手机客户端 介绍
A peptide hormone activator of GC-C
Canonical SMILES O=C(N[C@H](C(N[C@H](C(N[C@](CSSC[C@]1([H])NC([C@@]([C@H](O)C)([H])NC(CNC([C@@H]2CCCN2)=O)=O)=O)([H])C(N[C@@](C3=O)([H])[C@H](O)C)=O)=O)C)=O)C)[C@](NC([C@@H](NC([C@@](CSSC[C@H](NC(CN3)=O)C(O)=O)([H])NC(C(NC([C@@H](NC1=O)CCC(O)=O)=O)[C@@H](C)CC)=O)=O)C)=O)([H])CC(C=C4)=CC=C4O.OC(C(F)(F)F)=O
分子式 C58H87N15O21S4·XCF3COOH
分子量 1458.7
溶解度 Water: 1 mg/ml
储存条件 -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

Guanylin is a peptide hormone activator of membrane-bound guanylate cyclase C (GC-C).1,2It contains four cysteines that can form disulfide bridges leading to two possible isoforms, with the active form containing disulfide bridges between Cys4and Cys12and Cys7and Cys15.1Guanylin is found in epithelial cells of the small intestine where it activates GC-C to increase intestinal chloride and fluid secretion.2,3,4Guanylin expression is reduced by 100- to 1,000-fold in greater than 85% of isolated tumors from patients with colorectal cancer compared with adjacent non-cancerous intestinal epithelial tissue.5

1.Nokihara, K., Wray, V., Ando, E., et al.Synthesis, solution structure, binding activity, and cGMP activation of human guanylin and its disulfide isomerRegul. Pept.70(2-3)111-120(1997) 2.de Sauvage, F.J., Keshav, S., Kuang, W.-J., et al.Precursor structure, expression, and tissue distribution of human guanylinProc. Natl. Acad. Sci. USA89(19)9089-9093(1992) 3.Hill, O., Kuhn, M., Zucht, H.-D., et al.Analysis of the human guanylin gene and the processing and cellular localization of the peptideProc. Natl. Acad. Sci. USA92(6)2046-2050(1995) 4.Forte, L.R., and Currie, M.G.Guanylin: A peptide regulator of epithelial transportFASEB J.9(8)643-650(1995) 5.Wilson, C., Lin, J.E., Snook, A.E., et al.The paracrine hormone for the GUCY2C tumor suppressor, guanylin, is universally lost in colorectal cancerCancer Epidemiol. Biomarkers Prev.23(11)2328-2337(2014)
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