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JS-K
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
JS-K图片
CAS NO: 205432-12-8
包装与价格：
包装 价格(元)
1mg 电议
5mg 电议

半岛bd体育手机客户端 介绍
JS-K 是一种 NO 供体，在生理 pH 值下与谷胱甘肽反应生成 NO。 JS-K 抑制 Jurkat T 急性淋巴细胞白血病细胞的增殖、诱导细胞凋亡并破坏细胞周期。
Cas No. 205432-12-8
化学名 4-[2-(2,4-dinitrophenoxy)-1-oxidodiazenyl]-1-piperazinecarboxylic acid, ethyl ester
Canonical SMILES O=[N](N1CCN(C(OCC)=O)CC1)=NOC(C=CC([N+]([O-])=O)=C2)=C2[N+]([O-])=O
分子式 C13H16N6O8
分子量 384.3
溶解度 DMF: 0.5 mg/ml,DMSO: 0.3 mg/ml,Ethanol: slightly soluble
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述 JS-K is a nitric oxide (NO) donor that reacts with glutathione to generate NO at physiological pH. It inhibits proliferation of HL-60 cells (IC50 = 0.5 uM), which is prevented by the glutathione precursor N-acetyl-L-cysteine , and inhibits growth of the solid tumor cell lines PPC-1, DLD-1, and Meth A. It decreases tumor volume by over 50% in an HL-60 mouse xenograft model when used at a dose of 4 uMol/kg, i.v., three times per week. JS-K inhibits proliferation, induces apoptosis, and disrupts the cell cycle of Jurkat T acute lymphoblastic leukemia cells. It also induces S-nitrosylation of β-catenin followed by dose-dependent degradation of nuclear β-catenin and S-nitrosylated nuclear β-catenin levels.
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