Gallocyanine 是一种合成蓝色染料，通过破坏 DKK1/LRP6 相互作用来阻断 DKK1 抑制活性。
| Cas No. |
1562-85-2 |
| 别名 |
花菁 |
| Canonical SMILES |
OC(C1=CC(O)=C(O)C2=[O+]C3=CC(N(C)C)=CC=C3N=C21)=O.[Cl-] |
| 分子式 |
C15H13N2O5?Cl |
| 分子量 |
336.7 |
| 溶解度 |
DMSO 74 mg/mL (219.76 mM) |
| 储存条件 |
Store at -20°C |
| General tips |
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition |
Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 半岛bd体育手机客户端 描述 |
Gallocyanine is a small molecule blue dye used to stain nuclei. It is known to inhibit Dickkopf-1 (Dkk1), an antagonist of the Wnt pathway. Gallocyanine can disrupt the interaction of Dkk1 with its receptor LRP5/6 (IC50 = 3 ?M), thereby activating Wnt/β-catenin signaling. Modulation of the Dkk1-LRP5/6 interaction via gallocyanine has been shown to inhibit prostaglandin J2-induced tau phosphorylation at serine396 in primary cortical neurons in vitro. |
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