Hedgehog signaling activator; brain penetrant and orally bioavailable
| Cas No. |
946002-48-8 |
| Canonical SMILES |
COC1=C(CN([C@@H]2CC[C@@H](NC)CC2)C(C3=C(Cl)C4=C(C(F)=CC=C4F)S3)=O)C=C(C5=CC=NC=C5)C=C1 |
| 分子式 |
C29H28ClF2N3O2S |
| 分子量 |
556.07 |
| 溶解度 |
Soluble in DMSO |
| 储存条件 |
Store at -20°C |
| General tips |
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition |
Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 半岛bd体育手机客户端 描述 |
Potent Hedgehog signaling activator (EC50 = 0.4 nM). Orally bioavailable and brain penetrant. Brunton et al (2009) Potent agonists of the Hedgehog signaling pathway. Bioorg.Med.Chem.Lett. 19 4308 PMID:19500978 |
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