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Ipidacrine

本半岛bd体育手机客户端不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

62732-44-9

包装与价格：

半岛bd体育手机客户端介绍

2,3,5,6,7,8-Hexahydro-1H-cyclopenta[b]quinolin-9-amine 是一种药物活性化合物，是一种促智剂，可作为胆碱酯酶抑制剂，用于治疗阿尔茨海默病 [1 ]。

Cas No.	62732-44-9
别名	伊匹达克林
Canonical SMILES	NC1=C(CCC2)C2=NC3=C1CCCC3
分子式	C₁₂H₁₆N₂
分子量	188.3
溶解度	DMF: 25 mg/ml,DMSO: 25 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
储存条件	-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端描述	Ipidacrine is an inhibitor of acetylcholinesterase (AChE; IC₅₀= 270 nM).¹It induces long-term potentiation (LTP) in rat hippocampal slices, an effect that can be blocked by the muscarinic antagonists atropine or pirenzepine , when used at a concentration of 10 ?M.²Ipidacrine (0.03-1 mg/kg) prevents memory deficits induced by the anticholinergic agent scopolamine in the passive avoidance test in rats.² 1.Ogura, H., Kosasa, T., Kuriya, Y., et al.Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitroMethods Find. Exp. Clin. Pharmacol.22(8)609-613(2000) 2.Yoshida, S., and Suzuki, N.Antiamnesic and cholinomimetic side-effects of the cholinesterase inhibitors, physostigmine, tacrine and NIK-247 in ratsEur. J. Pharmacol.250(1)117-124(1993)