| CAS NO: | 1418112-77-2 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 1418112-77-2 |
| 别名 | AZD4721; RIST4721 |
| 分子式 | C19H25FN4O5S2 |
| 分子量 | 472.55 |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 半岛bd体育手机客户端 描述 | AZD4721 (RIST4721) is the potent and orally active antagonist of acidic CXC chemokine receptor 2 (CXCR2). AZD4721 has the potential for the research of inflammatory disease[1]. Assessment of Pharmacokinetics (PK) profile of AZD4721 (RIST4721) in rat and dog[1]. In Vivo PK Rat Dog Predicted hepatic metabolic CL (ml/min per kilogram)1.70.80 Observed CL (ml/min per kilogram)2.40.50 CLrenal (mL/min per kilogram)biliary (mL/min per kilogram)intc1.40.6 VSS (l/kg)0.190.15 T1/2 (h) (PO)1.33.7 (2.7)(8.4) F (%)4582 [1]. Gardiner P, et al. Plasma Protein Binding as an Optimizable Parameter for Acidic Drugs. Drug Metab Dispos. 2019;47(8):865-873. |
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