| CAS NO: | 1031206-36-6 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 1031206-36-6 |
| Canonical SMILES | CC1=CC=C(OC/C(C2=O)=C\C3=CC=C(OC)C(O)=C3)C2=C1 |
| 分子式 | C18H16O4 |
| 分子量 | 296.3 |
| 溶解度 | DMSO: 5 mg/ml,Ethanol: 1 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 半岛bd体育手机客户端 描述 | IMS 2186 is an anti-choroidal neovascularization agent.1It inhibits proliferation of NIH3T3 mouse and IMR-90 human fibroblasts (IC50s = 0.5-3 ?M), as well as in a panel of eight human cancer cell lines, including ovarian, lung, colon, and pancreatic cancer cells (IC50s = 0.3-3 ?M). IMS 2186 (10 ?M) decreases migration of THP-1 macrophages in wound healing and chamber assays. Subcutaneous administration of IMS 2186 (20 ?g/animal) inhibits VEGF-induced blood vessel formation in a MatrigelTMplug assay in mice. It reduces ocular leakage, as well as cellular proliferation and infiltration in a rat model of laser-induced choroidal neovascularization when administered intravitreally at a dose of 100 ?g/eye. 1.Falkenstein, I.A., Cheng, L., Wong-Staal, F., et al.Toxicity and intraocular properties of a novel long-acting anti-proliferative and anti-angiogenic compound IMS2186Curr. Eye Res.33(7)599-609(2008) |
m.cnreagent.com
