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UCN-02
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
UCN-02图片
CAS NO: 121569-61-7
包装与价格：
包装 价格(元)
1mg 电议
5mg 电议

半岛bd体育手机客户端 介绍
UCN-02 (7-epi-Hydroxystaurosporine) 是一种选择性蛋白激酶 C (PKC) 抑制剂，由 Streptomyces N-12 菌株产生，对 PKC 和蛋白激酶 A (PKA) 的 IC50 分别为 62 nM 和 250 nM。 UCN-02 (7-epi-Hydroxystaurosporine) 对 HeLa S3 细胞的生长具有细胞毒性作用。
Cas No. 121569-61-7
别名 7-epi-hydroxy Staurosporine
化学名 (3S,9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
Canonical SMILES [H][C@]12N(C3=C(N([C@](O2)(C)[C@H](OC)[C@H](NC)C1)C4=C5C=CC=C4)C5=C([C@H](O)NC6=O)C6=C37)C8=C7C=CC=C8
分子式 C28H26N4O4
分子量 482.5
溶解度 Ethanol: 1 mg/ml
储存条件 Store at -20℃
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

UCN-02 is a derivative of staurosporine and a stereoisomer of UCN-01, which has been first isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite [1]. UCN-02 is protein kinase C inhibitor [1].

Protein kinase C (PKC), which can phosphorylate serine and threonine, is a family of protein kinase enzymes involved in regulating the function of other proteins. Protein kinase C plays an important role in several signal transduction cascades. Protein kinase C has been implicated in modulating membrane structure events, mediating immune responses, regulating transcription, learning and memory, and regulating cell growth [2].

UCN-02 inhibited protein kinase C with a slightly reduced potency than UCN-01. The IC50 values were 62 and 4.1 nM for UNC-02 and UCN-01, respectively. UCN-02 was cytotoxic to the growth of HeLa S3 cells.

References:
[1] Takahashi, I. ,Saitoh, Y.,Yoshida, M., et al. UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities. J.Antibiot.(Tokyo) 42(4), 571-576 (1989).
[2] Newton A C. Protein kinase C: structure, function, and regulation[J]. Journal of Biological Chemistry, 1995, 270(48): 28495-28498.
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