L-erythro Sphingosine is a synthetic stereoisomer of sphingosine (d18:1).
| Cas No. | 6036-75-5 |
| 别名 | 双琥珀酰亚胺辛二酸酯 |
| Canonical SMILES | OC[C@@H](N)[C@@H](O)/C=C/CCCCCCCCCCCCC |
| 分子式 | C18H37NO2 |
| 分子量 | 299.5 |
| 溶解度 | Chloroform: soluble,DMSO: soluble,Ethanol: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
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描述 | L-erythro Sphingosine is a synthetic stereoisomer of sphingosine (d18:1) . It inhibits protein kinase C (PKC) in vitro (IC50 = 3.3 mol%) and superoxide generation induced by phorbol 12-myristate 13-acetate in neutrophils as well as reduces growth of CHO cells (IC50s = 1.3 and 2 μM, respectively). L-erythro Sphingosine also inhibits dephosphorylation of the tumor suppressor retinoblastoma gene product (pRb; EC50 = 5 μM) and growth of MOLT-4 acute lymphoblastic leukemia cells (IC50 = 3.7 μM). |
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