生物活性

PF-06447475是一种高效，选择性，脑渗透性LRRK2抑制剂，对Wt LRRK2/G2019S LRRK2的IC50分别为3 nM/11 nM。

靶点信息

LRRK2	G2019S LRRK2
3nM	11nM

化学数据

目录号	A15504
作用机制	Inhibitor (抑制剂)
M. Wt	305.33
Formula	C17H15N5O
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1527473-33-1
Synonyms	PF06447475, PF 06447475
SMILES	C1COCCN1C2=NC=NC3=C2C(=CN3)C4=CC=CC(=C4)C#N

溶解度

In vitro	DMSO	56 mg/mL (183.4 mM)
	Water	Insoluble
	Ethanol	Insoluble
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.75 mL	163.76 mL	327.51 mL
0.5 mM	6.55 mL	32.75 mL	65.5 mL
1 mM	3.28 mL	16.38 mL	32.75 mL
5 mM	0.66 mL	3.28 mL	6.55 mL

*The above data is based on the productmolecular weight 305.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.