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(±)-Thalidomide-d4
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(±)-Thalidomide-d4图片
CAS NO: 1219177-18-0
包装与价格：
包装 价格(元)
1mg 电议
5mg 电议

半岛bd体育手机客户端 介绍
(±)-Thalidomide-d4 是氘标记的 Thalidomide。
Cas No. 1219177-18-0
别名 沙利度胺 D4
Canonical SMILES O=C(C1=C2C([2H])=C([2H])C([2H])=C1[2H])N(C3C(NC(CC3)=O)=O)C2=O
分子式 C13H6D4N2O4
分子量 262.3
溶解度 DMF: 12 mg/ml,DMSO: 12 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.11 mg/ml
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

(±)-Thalidomide-d4 is intended for use as an internal standard for the quantification of (±)-thalidomide by GC- or LC-MS. (±)-Thalidomide is an immunomodulatory and antiproliferative compound that interacts directly with the protein CRBN (IC50 = 8.5 nM), a ubiquitously-expressed E3 ligase, and CRBN-DDB1 complexes.1,2

|1. Ito, T., Ando, H., Suzuki, T., et al. Identification of a primary target of thalidomide teratogenicity. Science 327(5971), 1345-1350 (2010).|2. Lopez-Girona, A., Mendy, D., Miller, K., et al. Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia 26(11), 2326-2335 (2012).
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