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Ac-DEVD-CHO(trifluoroacetate salt)
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Ac-DEVD-CHO(trifluoroacetate salt)图片
包装与价格：
包装 价格(元)
500?g 电议
1mg 电议
5mg 电议
10mg 电议

半岛bd体育手机客户端 介绍
A dual caspase3/caspase7 inhibitor
Canonical SMILES CC(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C([H])=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
分子式 C20H30N4O11?XCF3COOH
分子量 502.5
溶解度 DMF: 25 mg/ml,DMSO: 25 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件 -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

Ac-DEVD-CHO is a potent inhibitor of the Group II caspases, caspase-3 and caspase-7 (Kis = 0.23 and 1.6 nM, respectively).1,2Notably, it also inhibits other caspases (Kis = 18, 1710, 132, 205, 31, 0.92, 60, and 12 nM for caspases-1, -2, -4, -5, -6, -8, -9, and -10, respectively).1Caspase inhibitors in the aldehyde form, like this compound, are typically reversible, whereas methyl ketone forms, like Ac-DEVD-CMK , are irreversible.1Caspase inhibitors interfere with the initiation of apoptosis and have numerous possible clinical applications.3

1.Garcia-Calvo, M., Peterson, E.P., Leiting, B., et al.Inhibition of human caspases by peptide-based and macromolecular inhibitorsJ. Biol. Chem.273(49)32608-32613(1998) 2.Talanian, R.V., Quinlan, C., Trautz, S., et al.Substrate specificities of caspase family proteasesJ. Biol. Chem.272(15)9677-9682(1997) 3.Nicholson, D.W., Ali, A., Thornberry, N.A., et al.Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosisNature37637-43(1995)
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