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Phenylbutazone-d9
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Phenylbutazone-d9图片
CAS NO: 1189479-75-1
包装与价格：
包装 价格(元)
500 ?g 电议
1mg 电议
5mg 电议

半岛bd体育手机客户端 介绍
An internal standard for the quantification of phenylbutazone
Cas No. 1189479-75-1
别名 保泰松 d9
Canonical SMILES O=C1C(C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])C(N(C2=CC=CC=C2)N1C3=CC=CC=C3)=O
分子式 C19H11D9N2O2
分子量 317.4
溶解度 Methanol: soluble
储存条件 -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

Phenylbutazone-d9is intended for use as an internal standard for the quantification of phenylbutazone by GC- or LC-MS. Phenylbutazone is a non-steroidal anti-inflammatory drug and an inhibitor of the peroxidase activity of COX (IC50= ~100 ?M in the presence of hydrogen peroxide).1It also inhibits prostaglandin I synthase (IC50= ~25 ?M in the presence of hydrogen peroxide). Phenylbutazone (2 mg/kg) reduces increases in type II collagen levels in the inflamed joints of an equine model of LPS-induced acute synovitis.2Formulations containing phenylbutazone have been used in the treatment of lameness in horses.

1.Reed, G.A., Griffin, I.O., and Eling, T.E.Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for peroxidative metabolismMol. Pharmacol.27(1)109-114(1985) 2.de Grauw, J.C., van Loon, J.P.A.M., van de Lest, C.H.A., et al.In vivo effects of phenylbutazone on inflammation and cartilage-derived biomarkers in equine joints with acute synovitisVet. J.201(1)51-56(2014)
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