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2-Amino-3,8-dimethylimidazo-[4,5-f]-quinoxaline
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
2-Amino-3,8-dimethylimidazo-[4,5-f]-quinoxaline图片
CAS NO: 77500-04-0
包装与价格：
包装 价格(元)
5mg 电议
10mg 电议
25mg 电议

半岛bd体育手机客户端 介绍
A food-derived carcinogen
Cas No. 77500-04-0
别名 2-氨基-3,8-二甲基咪唑并喹喔啉
Canonical SMILES NC(N1C)=NC2=C1C=CC3=NC=C(C)N=C32
分子式 C11H11N5
分子量 213.2
溶解度 DMSO: slightly soluble,Methanol: slightly soluble
储存条件 -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

2-Amino-3,8-dimethylimidazo-[4,5-f]-quinoxaline (MeIQx) is a food-derived carcinogen that has been found in high temperature-cooked fish and meats.1It is activated by hydroxylation and subsequent O-acetylationviathe cytochrome P450 (CYP) isoform CYP1A2 and N-acetyltransferase 2, respectively, in UV5 cells expressing the human enzymes to a metabolite that reacts with DNA to form adducts.2MeIQx (200 and 400 ppm in the diet) induces tumor formation in rats.3

1.Johansson, M.A., and J?gerstad, M.Occurrence of mutagenic/carcinogenic heterocyclic amines in meat and fish products, including pan residues, prepared under domestic conditionsCarcinogenesis15(8)1511-1518(1994) 2.Metry, K.J., Neale, J.R., Doll, M.A., et al.Effect of rapid human N-acetyltransferase 2 haplotype on DNA damage and mutagenesis induced by 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline (MeIQx)Mutat. Res.684(1-2)66-73(2010) 3.Kushida, H., Wakabayashi, K., Sato, H., et al.Dose-response study of MeIQx carcinogenicity in F344 male ratsCancer Lett.83(1-2)31-35(1994)
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