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BIO-1211(trifluoroacetate salt)
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
BIO-1211(trifluoroacetate salt)图片
包装与价格：
包装 价格(元)
1mg 电议
5mg 电议
10mg 电议

半岛bd体育手机客户端 介绍
A peptide inhibitor of α4β1 integrin
Canonical SMILES CC(C=CC=C1)=C1NC(NC(C=C2)=CC=C2CC(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N3[C@@H](CCC3)C(O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
分子式 C36H48N6O9? XCF3COOH
分子量 708.8
溶解度 DMSO: soluble
储存条件 -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

BIO-1211 is a peptide inhibitor of α4β1 integrin (IC50= 0.004 ?M).1It is selective for α4β1 integrin over α4β7 (IC50= 2 ?M), as well as α1β1, α5β1, α6β1, αLβ2, and αIIbβ3 (IC50s = >100 ?M for all). BIO-1211 binds to α4β1 (IC50= 1 nM) and inhibits Jurkat cell adhesion (IC50= 4 nM). Inhaled administration of BIO-1211 (3 mg/animal) prevents carbachol-induced airway hyperresponsiveness in an ovine model of allergy-induced asthma.

1.Lin, K.c., Ateeq, H.S., Hsiung, S.H., et al.Selective, tight-binding inhibitors of integrin α4β1 that inhibit allergic airway responsesJ. Med. Chem.42(5)920-934(1999)
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