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WCK-4234
本半岛bd体育手机客户端 不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
WCK-4234图片
CAS NO: 1804915-68-1
包装与价格:
包装 价格(元)
5mg 电议
10mg 电议
25mg 电议
50mg 电议

半岛bd体育手机客户端 介绍
WCK-4234 是一种有效的 β-内酰胺酶抑制剂。WCK-4234 抑制 A、C 和 D 类 β-内酰胺酶活性。WCK-4234 缺乏直接的抗菌活性。WCK-4234 通过OXA-48/OXA-181 或 KPC 酶,或结合不渗透性, AmpC 或 ESBL 活性,增强亚胺培南和美罗培南对肠杆菌科细菌的抗菌作用作用。WCK-4234 明显克服了由 OXA (class D) 型碳青霉烯酶介导的抗性。
Cas No. 1804915-68-1
别名 阿维巴坦杂质46
分子式 C7H8N3NaO5S
分子量 269.21
储存条件 -20°C, away from moisture
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

WCK-4234 is a potent β-lactamase inhibitor. WCK-4234 inhibits class A, C, and D β-lactamases activity. WCK-4234 lacks direct antibacterial activity. WCK-4234 potentiates imipenem and meropenem against Enterobacteriaceae with OXA-48/OXA-181 or KPC enzymes, or with combinations of impermeability and AmpC or ESBL activity. WCK-4234 distinctively overcomes resistance mediated by OXA-type carbapenemases[1][2].

[1]. Iregui A, et al. Activity of Meropenem with a Novel Broader-Spectrum β-Lactamase Inhibitor, WCK 4234, against Gram-Negative Pathogens Endemic to New York City. Antimicrob Agents Chemother. 2019 Dec 20;64(1):e01666-19.
[2]. Mushtaq S, et al. WCK 4234, a novel diazabicyclooctane potentiating carbapenems against Enterobacteriaceae, Pseudomonas and Acinetobacter with class A, C and D β-lactamases. J Antimicrob Chemother. 2017 Jun 1;72(6):1688-1695.

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