RMC-5552 是一种高效、选择性的 mTORC1 抑制剂。RMC-5552 抑制 mTORC1 底物 pS6K 和 p4EBP1 磷酸化的 IC50 值分别为 0.14 nM 和 0.48 nM。RMC-5552 具有抗肿瘤活性。
| Cas No. |
2382768-62-7 |
| 分子式 |
C93H136N10O24 |
| 分子量 |
1778.13 |
| 溶解度 |
DMSO : 166.67 mg/mL (93.73 mM; Need ultrasonic) |
| 储存条件 |
Store at -20°C |
| General tips |
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition |
Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 半岛bd体育手机客户端 描述 |
RMC-5552 is a potent and selective inhibitor of mTORC1. RMC-5552 inhibits phosphorylation of mTORC1 pS6K and p4EBP1 with IC50s of 0.14 nM and 0.48 nM, respectively. RMC-5552 has anti-cancer activity. |
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