NV-5138 hydrochloride - 半岛电竞官方网址

您好，欢迎来到半岛电竞官方网址！ [ 登录] [ 免费注册]

立即咨询

咨询类型：

采购售后

*姓名：

*电话：

*单位：

Email：

*留言内容：

请详细说明您的需求。

*验证码：

NV-5138 hydrochloride

本半岛bd体育手机客户端不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

半岛bd体育手机客户端介绍

NV-5138 hydrochloride 是一种亮氨酸类似物，是首个具有选择性的、口服活性的脑内的 mTORC1 的激动剂，与 Sestrin2 结合。NV-5138 hydrochloride 可用于抗抑郁的生物研究。

分子式	C₇H₁₄ClF₂NO₂
分子量	217.64
溶解度	DMSO : 250 mg/mL (1148.69 mM; Need ultrasonic)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端描述	NV-5138 hydrochloride, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 hydrochloride is used for antidepressant studies[1][2]. NV-5138 is found to be essentially 100% orally bioavailable with an elimination half-life in plasma of ~ 3 h determined following intravenous and oral dosing in rats[1].NV-5138 (160 mg/kg, po, single dose) rapidly increases levels of phospho-mTOR as well as the downstream targets, phospho-p70S6K1, and phosphor-4EB-P1, in synaptosomal preparations of PFC[2].NV-5138 (80 mg/kg, po, daily for a total of 7 days) also produces antidepressant effects[2]. [1]. Sengupta S, et al. Discovery of NV-5138, the first selective Brain mTORC1 activator. Sci Rep. 2019 Mar 11;9(1):4107. [2]. Kato T, et al. Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation. J Clin Invest. 2019 Apr 16;129(6):2542-2554.