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Adenylosuccinic Acid(ammonium salt)
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Adenylosuccinic Acid(ammonium salt)图片
包装与价格：
包装 价格(元)
10mg 电议
25mg 电议
50mg 电议
100mg 电议

半岛bd体育手机客户端 介绍
A purine nucleotide and an intermediate in the purine nucleotide cycle
Canonical SMILES [O-]P(OC[C@H]([C@@H](O)[C@H]1O)O[C@@]1([H])N2C=NC3=C(N[C@@H](CC([O-])=O)C([O-])=O)N=CN=C32)([O-])=O.[NH4+].[NH4+].[NH4+].[NH4+]
分子式 C14H14N5O11P·4NH4
分子量 531.4
溶解度 PBS (pH 7.2): 10 mg/ml
储存条件 -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

Adenylosuccinic acid is a purine nucleotide and an intermediate in the purine nucleotide cycle.1It is converted into AMP and fumarate by adenylosuccinate lyase in the cytosol. Adenylosuccinic acid (10 ?M) inhibits calcium-induced activation of non-selective cation channels in isolated rat brown adipocytes in a patch-clamp assay.2Adenylosuccinic acid (10 ?M) increases glucose-induced insulin exocytosis in 832/13 INS-1 pancreatic β-cells.3It induces contractions in isolated guinea pig uterus strips when used at a concentration of 100 ?M.4

1.Waarde, A.Operation of the purine nucleotide cycle in animal tissuesBiol. Rev. Camb. Philos. Soc.63(2)259-298(1988) 2.Halonen, J., and Nedergaard, J.Adenosine 5’-monophosphate is a selective inhibitor of the brown adipocyte nonselective cation channelJ. Membr. Biol.188(1)183-197(2002) 3.Gooding, J.R., Jensen, M.W., Dai, X., et al.Adenylosuccinate is an insulin secretagogue derived from glucose-induced purine metabolismCell Rep.13(1)157-167(2015) 4.Nishida, Y., and Miyamoto, T.Contractile effect of succinylpurines on guinea pig uterusGen. Pharmacol.19(2)277-279(1988)
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