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6-Methylmercaptopurine
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
6-Methylmercaptopurine图片
CAS NO: 50-66-8
包装与价格：
包装 价格(元)
50mg 电议
100mg 电议
250mg 电议
1 g 电议

半岛bd体育手机客户端 介绍
A metabolite of 6-mercaptopurine
Cas No. 50-66-8
别名 6-甲巯基嘌呤
Canonical SMILES CSC1=C2NC=NC2=NC=N1
分子式 C6H6N4S
分子量 166.2
溶解度 DMF: 15 mg/ml,DMSO: 30 m/gml
储存条件 -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

6-Methylmercaptopurine (6-MMP) is a metabolite of the purine synthesis and interconversion inhibitor 6-mercaptopurine .1It is formed from 6-MPviamethylation by thiopurine S-methyltransferase. Levels of 6-MMP are increased in patients with altered thiopurine metabolism and associated with therapeutic resistance to 6-MP.2

1.Rieder, M.J., and Carleton, B.Pharmacogenomics and adverse drug reactions in childrenFront. Genet.578(2014) 2.van Egmond, R., Chin, P., Zhang, M., et al.High TPMT enzyme activity does not explain drug resistance due to preferential 6-methylmercaptopurine production in patients on thiopurine treatmentAliment. Pharmacol. Ther.35(10)1181-1189(2012)
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