生物活性

SGC 707是PRMT3的有效变构抑制剂（IC50 = 50 nM），其选择性是其他甲基转移酶和其他非表观遗传靶标的100倍以上。

靶点信息

PRMT3	PRMT3
31 nM	53 nM(Kd)

化学数据

目录号	A15450
作用机制	Inhibitor (抑制剂)
M. Wt	298.3
Formula	C16H18N4O2
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1687736-54-4
Synonyms	SGC707, SGC-707
SMILES	C1CCN(C1)C(=O)CNC(=O)NC2=CC3=C(C=C2)C=NC=C3

溶解度

In vitro	DMSO	51 mg/mL (170.95 mM)
	Water	Insoluble
	Ethanol	Warmed: 51 mg/mL (170.95 mM)
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	33.52 mL	167.62 mL	335.23 mL
0.5 mM	6.7 mL	33.52 mL	67.05 mL
1 mM	3.35 mL	16.76 mL	33.52 mL
5 mM	0.67 mL	3.35 mL	6.7 mL

*The above data is based on the productmolecular weight 298.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.