生物活性
TRV130 HCl (Oliceridine)是一种新型的μ-opioid 受体（MOR）G蛋白偏向配体。诱导强大的G蛋白信号传导（pEC50 = 8.1），效力和功效与吗啡相似，但β-arrestin募集和受体内在化作用要低得多。
化学数据
| 目录号 |
A15444 |
| 作用机制 |
Agonist (激动剂) |
| M. Wt |
423.01 |
| Formula |
C22H31ClN2O2S |
| Purity |
>99% |
| Storage |
Store lyophilized at -20?C, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. |
1401031-39-7 |
| Synonyms |
TRV-130, TRV 130 |
| SMILES |
COC1=C(SC=C1)CNCCC2(CCOC3(C2)CCCC3)C4=CC=CC=N4.Cl |
储备液配制
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 0.1 mM |
23.64 mL |
118.2 mL |
236.4 mL |
| 0.5 mM |
4.73 mL |
23.64 mL |
47.28 mL |
| 1 mM |
2.36 mL |
11.82 mL |
23.64 mL |
| 5 mM |
0.47 mL |
2.36 mL |
4.73 mL |
*The above data is based on the productmolecular weight 423.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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