EGFR-IN-17 是一种有效且选择性的表皮生长因子受体（EGFR）抑制剂（IC50 0.0002 μM），用于克服 C797S 介导的耐药性。
| 分子式 |
C27H31ClN7O3P |
| 分子量 |
568.01 |
| 溶解度 |
DMSO : 12.5 mg/mL (22.01 mM; ultrasonic and warming and heat to 60℃) |
| 储存条件 |
Store at -20°C |
| General tips |
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition |
Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 半岛bd体育手机客户端 描述 |
EGFR-IN-17 is a potent and selective inhibitor of the epidermal growth factor receptor ( IC50 0.0002 μM) to overcome C797S-mediated resistance. [1]. Finlay MRV, et al. Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S-Mediated Resistance. J Med Chem. 2021 Sep 23;64(18):13704-13718. |
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