ENPP1-IN-2 是一种有效的外核苷酸焦磷酸酶/磷酸二酯酶 (ENPP1) 抑制剂，对重组人 ENPP-1 的 IC50 为 32.38 nM。ENPP1-IN-2 具有抗肿瘤活性。
| Cas No. | 2687222-59-7 |
| 分子式 | C15H22ClN5O4S |
| 分子量 | 403.88 |
| 溶解度 | DMSO : 9.62 mg/mL (23.82 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
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描述 | ENPP1-IN-2 is a potentEctonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1)inhibitor with anIC50value of 32.38 nM for recombinant human ENPP-1. ENPP1-IN-2 has anti-tumor activity[1]. ENPP1-IN-2 (compound 015) (50 mg/kg; IP; BID, for 31 days) significantly inhibits tumor growth[1]. | Animal Model: | Female C57BL/6 mice (4-6 weeks; implanted subcutaneously with 2×105MC38 cells)[1] | | Dosage: | 50 mg/kg | | Administration: | IP; BID, for 31 days (given a single 10 Gy exposure of focal radiation to the tumor site) | | Result: | Significantly inhibited tumor growth. |
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