Description: CMP-5 HCl, the hydrochloride salt of CMP-5 (PRMT5-IN-5), is a potent, first-in-class and specific PRMT5 inhibitor with anticancer (B-cell lymphomas) and immunomodulatory activity. It displays no activity against other type I (PRMT1 and PRMT4) and type II (PRMT7) enzymes. CMP-5 blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells. Inhibition of PRMT5 leads to lost recruitment of a PRMT5/p65/HDAC3-repressive complex on the miR96 promoter, restored miR96 expression, and PRMT5 downregulation.
References:
[1]. Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation. Blood. 2015 Apr 16;125(16):2530-43.
[2]. PRMT5-Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis. J Immunol. 2017 Feb 15;198(4):1439-1451
Related CAS#: 1030021-40-9 (HCl) 880813-42-3 (free base)
纯度：≥98%
CAS：1030021-40-9
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