DT-061 - 半岛电竞官方网址

	Name: DT-061 CAS#: 1809427-19-7 Chemical Formula: C25H23F3N2O5S Exact Mass: 520.128 Molecular Weight: 520.5232
Storage	-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Technical Information	Synonym: DT 061; DT61; SMAP; DT-061; DT061; DT-61; DT 61 Chemical Name: N-((1R,2R,3S)-2-hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl)-4-(trifluoromethoxy)benzenesulfonamide InChi Key: WGKGADVPRVLHHZ-ZHRMCQFGSA-N InChi Code: InChI=1S/C25H23F3N2O5S/c26-25(27,28)35-16-12-14-17(15-13-16)36(32,33)29-18-6-5-9-21(24(18)31)30-19-7-1-3-10-22(19)34-23-11-4-2-8-20(23)30/h1-4,7-8,10-15,18,21,24,29,31H,5-6,9H2/t18-,21+,24+/m1/s1 SMILES Code: O=S(C1=CC=C(OC(F)(F)F)C=C1)(N[C@H]2[C@H](O)[C@@H](N3C4=C(C=CC=C4)OC5=CC=CC=C35)CCC2)=O

Name: DT-061
CAS#: 1809427-19-7
Chemical Formula: C25H23F3N2O5S
Exact Mass: 520.128
Molecular Weight: 520.5232

Storage

-20℃ for 3 years in powder form

-80℃ for 2 years in solvent

Technical Information

Synonym: DT 061; DT61; SMAP; DT-061; DT061; DT-61; DT 61
Chemical Name: N-((1R,2R,3S)-2-hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl)-4-(trifluoromethoxy)benzenesulfonamide
InChi Key: WGKGADVPRVLHHZ-ZHRMCQFGSA-N
InChi Code: InChI=1S/C25H23F3N2O5S/c26-25(27,28)35-16-12-14-17(15-13-16)36(32,33)29-18-6-5-9-21(24(18)31)30-19-7-1-3-10-22(19)34-23-11-4-2-8-20(23)30/h1-4,7-8,10-15,18,21,24,29,31H,5-6,9H2/t18-,21+,24+/m1/s1
SMILES Code: O=S(C1=CC=C(OC(F)(F)F)C=C1)(N[C@H]2[C@H](O)[C@@H](N3C4=C(C=CC=C4)OC5=CC=CC=C35)CCC2)=O

Target	PP2A[1].
In Vivo	DT-061 (5 mg/kg, oral gavage, 4 weeks) shows single-agent activity in inhibiting H358 or H441 xenograft growth. Additionally, the combination of DT-061 and AZD6244 is more significantly efficient[1]. Animal Model: 6- to 8-week-old male BALB/c nu/nu mice injected with H441 cells (5 × 106)[1]. Dosage: 5 mg/kg. Administration: Oral gavage for 4 weeks. Result: Showed activity in inhibiting tumor growth.
References	[1]. Sci Transl Med. 2018 Jul 18;10(450). pii: eaaq1093.

Target

PP2A[1].

In Vivo

DT-061 (5 mg/kg, oral gavage, 4 weeks) shows single-agent activity in inhibiting H358 or H441 xenograft growth. Additionally, the combination of DT-061 and AZD6244 is more significantly efficient[1]. Animal Model: 6- to 8-week-old male BALB/c nu/nu mice injected with H441 cells (5 × 106)[1]. Dosage: 5 mg/kg. Administration: Oral gavage for 4 weeks. Result: Showed activity in inhibiting tumor growth.

References

[1]. Sci Transl Med. 2018 Jul 18;10(450). pii: eaaq1093.

CAS NO:	1809427-19-7
规格:	≥98%

包装	价格(元)
10mg	电议
25mg	电议
50mg	电议
100mg	电议
250mg	电议