Verrucarin J is a natural inhibitor of cancer stem cell (CSC) self-renewal signalling pathways, which induces cell apoptosis with concomitant down regulation of key CSC specific genes- ALDH1, LGR5, OCT4 and CD133 in a dose-dependent manner. References: Udoh K, Parte S, Carter K, Mack A, Kakar SS. Targeting of Lung Cancer Stem Cell Self-Renewal Pathway by a Small Molecule Verrucarin J. Stem Cell Rev. 2019 Aug;15(4):601-611. doi: 10.1007/s12015-019-09874-7. PubMed PMID: 30835047; PubMed Central PMCID: PMC6626573.

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CAS：4643-58-7