Lycobetaine is a selective topoisomerase II beta poison and inhibits the growth of human tumour cells. Inhibition of cell growth was studied in the clonogenic assay on 21 human tumour xenografts (mean IC(50) = 0.8 microM). The growth of human leukaemia cell lines was also potently inhibited (mean IC(50) = 1.3 microM). References: Zhao H, Lu H, Gong T, Zhang Z. Nanoemulsion loaded with lycobetaine-oleic acid ionic complex: physicochemical characteristics, in vitro, in vivo evaluation, and antitumor activity. Int J Nanomedicine. 2013;8:1959-73. doi: 10.2147/IJN.S43892. Epub 2013 May 21. PubMed PMID: 23723698; PubMed Central PMCID: PMC3666662. 2: Baechler SA, Fehr M, Habermeyer M, Hofmann A, Merz KH, Fiebig HH, Marko D, Eisenbrand G. Synthesis, topoisomerase-targeting activity and growth inhibition of lycobetaine analogs. Bioorg Med Chem. 2013 Feb 1;21(3):814-23. doi: 10.1016/j.bmc.2012.11.011. Epub 2012 Nov 26. PubMed PMID: 23266176. 3: Barthelmes HU, Niederberger E, Roth T, Schulte K, Tang WC, Boege F, Fiebig HH, Eisenbrand G, Marko D. Lycobetaine acts as a selective topoisomerase II beta poison and inhibits the growth of human tumour cells. Br J Cancer. 2001 Nov 16;85(10):1585-91. PubMed PMID: 11720449; PubMed Central PMCID: PMC2363954. 4: Liu J, Yang SL, Xu B. Effects of lycobetaine on chromatin structure and activity of murine hepatoma cells. Sci China B. 1990 Dec;33(12):1459-65. PubMed PMID: 2282145. 5: Liu J, Yang SL, Xu B. Characteristics of the interaction of lycobetaine with DNA. Zhongguo Yao Li Xue Bao. 1989 Sep;10(5):437-42. PubMed PMID: 2618733. 6: He HM, Weng ZY. [Structure-activity-relationship study of the new anticancer drug lycobetaine (AT-1840)]. Yao Xue Xue Bao. 1989;24(4):302-4. Chinese. PubMed PMID: 2816392. 7: Wang ZW, Shu RS, Xu B. [Nucleolus segregation of tumor cells induced by actinomycin K and lycobetaine (author's transl)]. Zhongguo Yao Li Xue Bao. 1982 Mar;3(1):48-51. Chinese. PubMed PMID: 6178253. 8: Zhang SY, Lu FL, Yang JL, Wang LJ, Xu B. [Effect on animal tumors and toxicity of lycobetaine acetate (author's transl)]. Zhongguo Yao Li Xue Bao. 1981 Mar;2(1):41-5. Chinese. PubMed PMID: 6461201.

纯度：≥98%

CAS：61221-41-8