Streptomyces A-Factor is a microbial hormone found in Streptomyces griseus, A-factor at an extremely low concentration triggers streptomycin biosynthesis and cell differentiation by binding a repressor-type receptor protein (ArpA) and dissociating it from DNA. A factor plays a role in allowing the cell to grow healthy and to produce antibiotics in response to environmental conditions. References: Matselyukh B, Mohammadipanah F, Laatsch H, Rohr J, Efremenkova O, Khilya V. N-methylphenylalanyl-dehydrobutyrine diketopiperazine, an A-factor mimic that restores antibiotic biosynthesis and morphogenesis in Streptomyces globisporus 1912-B2 and Streptomyces griseus 1439. J Antibiot (Tokyo). 2015 Jan;68(1):9-14. doi: 10.1038/ja.2014.86. Epub 2014 Jul 9. PubMed PMID: 25005816.
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CAS:51311-41-2