STK899704 is a novel tubulin inhibitor, preventing the polymerization of purified tubulin in vitro and depolymerizing microtubule in cultured cells leading to mitotic arrest, associated with increased Cdc25C phosphorylation and the accumulation of both cyclin B1 and polo-like kinase 1 (Plk1), and apoptosis. References: Sakchaisri K, Kim SO, Hwang J, Soung NK, Lee KH, Choi TW, Lee Y, Park CM, Thimmegowda NR, Lee PY, Shwetha B, Srinivasrao G, Pham TT, Jang JH, Yum HW, Surh YJ, Lee KS, Park H, Kim SJ, Kwon YT, Ahn JS, Kim BY. Anticancer activity of a novel small molecule tubulin inhibitor STK899704. PLoS One. 2017 Mar 15;12(3):e0173311. doi: 10.1371/journal.pone.0173311. eCollection 2017. PubMed PMID: 28296906; PubMed Central PMCID: PMC5351965.

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CAS：371135-20-5