生物活性

LGK974是高效，选择性和口服生物利用性的豪猪抑制剂（Wnt信号拮抗剂），在Wnt信号报告基因测定和豪猪结合测定中IC50 <1 nM。

靶点信息

Porcn (TM3 cells)

化学数据

目录号	A12816
作用机制	Inhibitor (抑制剂)
M. Wt	396.44
Formula	C23H20N6O
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1243244-14-5
Synonyms	LGK974, LGK 974
SMILES	CC1=C(N=CC(=C1)CC(=O)NC2=NC=C(C=C2)C3=NC=CN=C3)C4=CC(=NC=C4)C

溶解度

In vitro (25°C)	DMSO	Warmed: 76 mg/mL (191.7 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+corn oil	4 mg/mL
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.22 mL	126.12 mL	252.24 mL
0.5 mM	5.04 mL	25.22 mL	50.45 mL
1 mM	2.52 mL	12.61 mL	25.22 mL
5 mM	0.5 mL	2.52 mL	5.04 mL

*The above data is based on the productmolecular weight 396.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.