Description: Ionomycin calcium (SQ-23377; SQ23377), the calcium salt of Ionomycin, is a selective and potent Ca 2+ ionophore. It is an antibiotic and polyether isolated from Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC). Its depletion of intracellular Ca 2+ stores may be linked to the induction of apoptosis.
References:
[1]. Liu C,et al. Characterization of ionomycin as a calcium ionophore. J Biol Chem. 1978 Sep 10;253(17):5892-4.
[2]. Chatila T, et al. Mechanisms of T cell activation by the calcium ionophore ionomycin. J Immunol. 1989 Aug 15;143(4):1283-9.
[3]. Gil-Parrado S, et al. Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members. J Biol Chem. 2002 Jul 26;277(30):27217-26.
Related CAS #:56092-81-0 (free acid) 56092-82-1 (calcium)
纯度：≥98%
CAS：56092-82-1
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