生物活性

PI-3065是p110δ激酶的小分子和选择性抑制剂，Ki值为1.5nM，IC50值为5nM。

Targets

Target	Value
p110δ	IC50: 15nM
p110β	IC50: 1078nM
p110α	IC50: 2299nM
mTOR	IC50: 9082nM
DNA-PK	IC50: >10000nM
p110γ	IC50: 27542nM

化学数据

目录号	A14338
作用机制	Inhibitor (抑制剂)
M. Wt	506.64
Formula	C27H31FN6OS
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	955977-50-1
Synonyms	PI3065, PI 3065
SMILES	C1CC1CN2CCN(CC2)CC3=CC4=C(S3)C(=NC(=N4)C5=C(C=CC6=C5C=CN6)F)N7CCOCC7

溶解度

In vitro	DMSO	Warmed: 50 mg/mL (98.68 mM)
	Water	Insoluble
	Ethanol	Insoluble
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.74 mL	98.69 mL	197.38 mL
0.5 mM	3.95 mL	19.74 mL	39.48 mL
1 mM	1.97 mL	9.87 mL	19.74 mL
5 mM	0.39 mL	1.97 mL	3.95 mL

*The above data is based on the productmolecular weight 506.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.