鍩哄洜鍚嶏細

BLOC1S4

浜у搧鍒悕锛欬p style="text-indent: 2em;">BCAS4L锛 BLOS4锛 CNO锛 BLOC1S4锛 biogenesis of lysosomal organelles complex 1 subunit 4锛 biogenesis of lysosomal organelles complex 1 subunit 4锛 biogenesis of lysosome-related organelles complex 1 subunit 4锛 BLOC-1 subunit 4锛 biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino锛 cappuccino homolog锛 protein cappuccino homolog锛 Cappuccino铔嬬櫧锛

鑳屾櫙淇℃伅锛欬div style="text-indent: 2em;">Biogenesis of lysosome-related organelles complex-1 (BLOC-1) is a multisubunit protein necessary for biogenesis of specialized organelles of the endosomal-lysosomal system (such as melanosomes and platelet-dense granules). The complex consists of coiled-coil-forming proteins Snapin, Pallidin, Cappuccino, Muted, BLOS1, BLOS2, and BLOS3. The localization of these proteins varies as they can be cytoplasmic, peripheral membrane bound or anchored to the vesicular membrane.Cappuccino, a primarily cytoplasmic protein, plays a role in the development of melanosomes, platelet-dense granules and other lysosome-related organelles. It interacts primarily with pallidin and Muted and has been implicated as an actin-nucleation factor that may play a role in crosstalk between microfilaments and microtubules.