Laudanosine is a recognized metabolite of atracurium and cisatracurium. Laudanosine decreases the seizure threshold, and thus it can induce seizures if present at sufficient threshold concentrations; however such concentrations are unlikely to be produced consequent to chemodegradable metabolism of clinically administered doses of cisatracurium or atracurium. References: Yang Y, Chen M, Kuang Y, Ye L, Zhang W. [Determination of atracurium and laudanosine in dog plasma during cardiopulmonary bypass by high performance liquid chromatography with fluorometric detection]. Se Pu. 2013 Jun;31(6):572-6. Chinese. PubMed PMID: 24063198.
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CAS:1699-51-0