靶标：
DIO3
半岛bd体育手机客户端 别名：
5DIII； D3； DIOIII； TXDI3； DIO3； iodothyronine deiodinase 3； iodothyronine deiodinase 3； thyroxine 5-deiodinase； deiodinase, iodothyronine type III； iodothyronine deiodinase, placental type； selenoprotein DIO3； thyroxine deiodinase type III (selenoprotein)； type 3 DI； type 3 iodothyronine selenodeiodinase； type-III 5' deiodinase； 甲状腺素5'脱碘酶3； 碘甲腺原氨酸脱碘酶Ⅲ(DIO3)；
背景信息：
The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in pregnant uterus, placenta, fetal and neonatal tissues, and thought to prevent premature exposure of developing fetal tissues to adult levels of thyroid hormones. It regulates circulating fetal thyroid hormone concentrations, and thus plays a critical role in mammalian development. Knockout mice lacking this gene exhibit abnormalities related to development and reproduction, and increased activity of this enzyme in infants with hemangiomas causes severe hypothyroidism. This protei
宿主：Rbt
类型：Pab
同种型:IgG
应用：WB
纯化方式：亲和纯化
偶联物：Unconjugated
性状：液体
存储溶液：参阅说明书
浓度：Batch dependent (Please refer to the vial label for the specific concentration.)
稀释比例: Optimal dilutions/concentrations should be determined by the end user
储存：经常使用则4°C保存。-20°C保存不超过两年。避免反复冻融。
注意事项：仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
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