ML303 是一种吡唑并吡啶类化合物， 是流感病毒非结构蛋白 1 (NS1) 的拮抗剂 (IC90 为 155 nM)，其对流感病毒H1N1亚型的 EC50 值为0.7 μM。
货号:ajcx38958
CAS:1638211-04-7
分子式:C21H16F3N3O2
分子量：399.37
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存： 现货

Background:

ML303 is a pyrazolopyridine influenza virus nonstructural protein 1 (NS1) antagonist (IC90 = 155 nM), with an EC50 of 0.7 μM for Influenza A virus H1N1[1].

ML303 (20 μM, 6 h) treatment restore IFN-β mRNA levels in MDCK cells[1].

[1]. Patnaik S, et al. Identification, design and synthesis of novel pyrazolopyridine influenza virus nonstructural protein 1 antagonists. Bioorg Med Chem Lett. 2019 May 1;29(9):1113-1119.