Azido-PEG5-CH2CO2H 是一种可降解 (cleavable) 的含 5 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。Azido-PEG5-CH2CO2H 还是一种 PROTAC linker，属于 PEG 类，可用于合成 PROTAC 分子。
货号:ajcx38538
CAS:217180-81-9
分子式:C12H23N3O7
分子量：321.33
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存： 现货

Background:

Azido-PEG5-CH2CO2H is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG5-CH2CO2H is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. Yong Zu Kim, et al. Antibody-drug conjugates comprising branched linkers and methods related thereto. WO2017089895A1.