ZK824190 hydrochloride 是一种口服有效的选择性尿激酶型纤溶酶原激活剂 (uPA) 抑制剂，可用于多发性硬化症的研究。ZK824190 hydrochloride 对 uPA，tPA 和 Plasmin 的 IC50 分别为 237，1600 和 1850 nM。
货号:ajcx38098
CAS:2629177-12-2
分子式:C22H21ClF2N2O4
分子量：450.86
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存： 现货

Background:

ZK824190 hydrochloride is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively[1].

ZK824190 (2 mg/kg; PO; Rats with EAE model) exhibits a relatively high oral availability and a moderate half time (T1/2=2.8 h)[1].

[1]. Islam I, et al. Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3372-3375.