Ly93 是一种口服有效的、鞘磷脂合成酶 (SMS2) 的选择性抑制剂，IC50 值为 91 nM。
货号:ajcx38632
CAS:1883528-69-5
分子式:C21H20N2O2
分子量：332.4
溶解度:DMSO : 250 mg/mL (752.11 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存： 现货

Background:

Ly93 is a selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with an IC50 of 91 nM[1].

Ly93 (100 mg/kg, i.g. once daily for 7 days) significantly decreases the plasma SM levels of C57BL/6J mice[1].Ly93 dose-dependently attenuates the atherosclerotic lesions in the root and the entire aorta as well as macrophage content in lesions, in apolipoprotein E gene knockout mice[1].

[1]. Li Y, et al. Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor. Eur J Med Chem. 2019 Feb 1;163:864-882.