生物活性

UNC2881是特异的Mer酪氨酸激酶抑制剂。

靶点信息

Mer	Tyro3	Axl
4.3 nM	250 nM	360 nM

化学数据

目录号	A14276
作用机制	Inhibitor (抑制剂)
M. Wt	463.58
Formula	C25H33N7O2
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1493764-08-1
Synonyms	UNC 2881, UNC-2881
SMILES	CCCCNC1=NC=C(C(=N1)NC2CCC(CC2)O)C(=O)NCC3=CC=C(C=C3)N4C=CN=C4

溶解度

In vitro	DMSO	80 mg/mL (172.57 mM)
	Water	Insoluble
	Ethanol	Warmed: 4 mg/mL (8.62 mM)
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.57 mL	107.86 mL	215.71 mL
0.5 mM	4.31 mL	21.57 mL	43.14 mL
1 mM	2.16 mL	10.79 mL	21.57 mL
5 mM	0.43 mL	2.16 mL	4.31 mL

*The above data is based on the productmolecular weight 463.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.