CO23 是一种选择性的 TRα (甲状腺激素受体)激动剂，用于调节生长发育。CO23 能够通过血脑屏障转运。
货号:ajcx39870
CAS:1370363-74-8
分子式:C19H18I2N2O4
分子量：592.17
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存： 现货

Background:

CO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation. CO23 was able to be transported through the blood-brain barrier[1].

CO23 (ip; 0.04-5.0 nmol/g) has ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses are equally effective. CO23 has no effect at the lowest dose of 0.04 nmol/g and increases Dio1 mRNA 5-, 10-, and 15-fold at the doses of 0.8, 2.5, and 5 nmol/g, respectively[1].

[1]. Grijota-Mart?nez C, et al. In vivo activity of the thyroid hormone receptor beta- and α-selective agonists GC-24 and CO23on rat liver, heart, and brain. Endocrinology. 2011 Mar;152(3):1136-42.