Pinacidil 是一种有效的钾通道 (potassium channel) 激活剂。Pinacidil 是一种抗高血压药,通过打开 K+-通道使血管平滑肌超极化。Pinacidil 显着改善再灌注功能和心脏顺应性。Pinacidil 具有直接的心脏保护作用。
货号:ajcx36440
CAS:60560-33-0
分子式:C13H19N5
分子量:245.32
溶解度:DMSO : 100 mg/mL (407.63 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:
现货
Background:
Pinacidil is a potent activator of potassium channel. Pinacidil is an antihypertensive agent which hyperpolarises vascular smooth muscle by opening K+-channels. Pinacidil significantly improves the reperfusion function and cardiac compliance. Pinacidil has direct cardioprotective efficacy[1].
[1]. Grover GJ, et al. Anti-ischemic effects of the potassium channel activators pinacidil and cromakalim and the reversal of these effects with the potassium channel blocker glyburide. J Pharmacol Exp Ther. 1989;251(1):98-104.
[2]. Hamilton TC, et al. Cromakalim, nicorandil and pinacidil: novel drugs which open potassium channels in smooth muscle. Gen Pharmacol. 1989;20(1):1-9.